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KMID : 1139819980020010193
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Journal of Dong - Eui Oriental Medicine
1998 Volume.2 No. 1 p.193 ~ p.204
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Effect of Pyungangaeulgyhyul-tang on CCl4 - induced liver cell injury
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Oh Se-Kwang
Kim Woo-Hwan
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Abstract
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This study was undertaken to determine if Pyungangaeuljyhyul-tang (PG) has a protective effect against CCL-induced liver cell injury in rabbits. Rabbits were treated intraperitoneally with 0.5㎖/㎏ of CCL₄. In experiments for PG effect, rabbits were pretreated with 2.5 ㎖ of PG for 24 hr before and 24 hr after injection of CCL₄. When rabbits were treated with CCL₄, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were increased compared with the control. Such an increase in enzyme activity was significantly inhibited by pretreatment of PG. CCL₄ treatment incrased lipid peroxidation, and its effect was prevented by PG. CCL₄ treatment resulted in a reduction of reduced glutathione (GSH) and an increase of oxidized glutathione (GSSG), which were attenuated by pretreatment of PG.
These results suggest that PG could be used in prevention and treatment of drug-induced liver cell injury. However, the precise mechanisms of PG protection remain to be determined.
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